Yes, fiber-cement behaves differently than wood. Key differences:
Surface prep is critical. Factory primer is often slick and chalky. You must wash it (TSP substitute, rinse well) and lightly sand (120-grit) to de-gloss and remove chalk. Skip this, paint peels in sheets.
Caulk differently. Don't caulk the horizontal lap joints (the "shadow line"). Fiber-cement expands/contracts less than wood but still moves; caulking traps moisture and causes paint failure. Only caulk vertical joints, corners, and around penetrations. Use high-quality polyurethane or STPE sealant (not silicone—unpaintable).
Back-prime cut ends. Any field-cut edge must be primed before installation. Unsealed ends wick water, causing swelling/delamination. Use oil-based or 100% acrylic primer.
Paint specs. Use 100% acrylic latex (satin or flat). Two coats. Minimum 4 mils DFT total. Dark colors (LRV < 20) increase thermal stress; check manufacturer's color restrictions (e.g., James Hardie prohibits certain dark hues).
Fastener heads. Spot-prime nail/screw heads if they breach the factory primer. Don't rely on topcoat alone.
Code/Standards: Follow ASTM C1186 (material) and manufacturer's written instructions (IRC R703.10.1). James Hardie, Allura, and Nichiha have slightly different joint/clearance specs—read the specific brand's guide.
Bottom line: Prep the factory primer aggressively, don't caulk laps, seal every cut end, and follow the brand's install manual.